Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LGALS3 | P17931 | 4/20 | 0.47 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.47 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.41 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.41 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878521 | 0.92 | LMNA (0.50) | MAPK1LGALS3LGALS8LGALS4KMT2A | |
| SCHEMBL23394602 | 0.92 | LMNA (0.50) | MAPK1LGALS3LGALS8LGALS4KMT2A | |
| SCHEMBL12248478 | 0.84 | LMNA (0.50) | MAPK1LGALS3LGALS8LGALS4KMT2A | |
| SCHEMBL15592385 | 0.84 | MAPK1 (0.52) | MAPK1LGALS3LGALS8LGALS4KMT2A | |
| SCHEMBL7889307 | 0.83 | LMNA (0.44) | LGALS3KMT2ALMNALGALS9LGALS1 | |
| SCHEMBL19786845 | 0.83 | LMNA (0.53) | MAPK1KMT2ALMNACYP3A4MAPT | |
| SCHEMBL13447791 | 0.83 | LMNA (0.51) | MAPK1KMT2ALMNACYP3A4MAPT | |
| SCHEMBL13447797 | 0.82 | LMNA (0.50) | MAPK1KMT2ALMNACYP3A4MAPT | |
| SCHEMBL12248448 | 0.82 | LMNA (0.50) | MAPK1KMT2ALMNACYP3A4MAPT | |
| SCHEMBL13117380 | 0.82 | LMNA (0.50) | MAPK1KMT2ALMNACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723509-B2 | Conjugated lipophilic group with a modified nucleotide is used to target disease gene, cells, tissue, for drug delivery to target tumor cells; ribose sugar of nucleotide is replaced with a cyclic carrier which has at least one attached phosphate or phosphorothioate group; biodrugs | ALNYLAM PHARMACEUTICALS (US) | 2010-05-25 | — | — | US | disclosed |