Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 12/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD1 | O95696 | 1/20 | 0.39 |
| ▸ | TAF1 | P21675 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14169090 | 0.79 | KMT2A (0.41) | ALDH1A1RXFP1KDM4EMEN1NPC1 | |
| SCHEMBL15267178 | 0.79 | ADORA3 (0.33) | ALDH1A1KDM4EMAPTL3MBTL1ADORA3 | |
| SCHEMBL14849938 | 0.78 | KMT2A (0.38) | ALDH1A1RXFP1KDM4EMEN1NPC1 | |
| SCHEMBL12355076 | 0.78 | ADORA3 (0.33) | KDM4EADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL23252363 | 0.74 | ALDH1A1 (0.53) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL29405395 | 0.71 | CYP1A2 (0.45) | CYP1B1ALDH1A1POLBRXFP1MEN1 | |
| SCHEMBL29406732 | 0.71 | CYP1A2 (0.45) | CYP1B1ALDH1A1POLBRXFP1MEN1 | |
| SCHEMBL3575204 | 0.71 | CYP1A2 (0.45) | CYP1B1ALDH1A1POLBRXFP1MEN1 | |
| SCHEMBL2679177 | 0.71 | CYP1A2 (0.45) | CYP1B1ALDH1A1POLBRXFP1MEN1 | |
| SCHEMBL19429348 | 0.70 | CA12 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207929-B1 | COLCHICINE DERIVATIVES FOR THE TREATMENT OF CANCER | CALIFORNIA PACIFIC MEDICAL CENTER (US) | 2021-05-26 | — | — | EP | disclosed |