Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23396287 | 0.78 | CYP1B1 (0.42) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL14169090 | 0.76 | KMT2A (0.41) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL15267178 | 0.76 | ADORA3 (0.33) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL14849938 | 0.76 | KMT2A (0.38) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL12355074 | 0.72 | TDP1 (0.37) | — | |
| SCHEMBL28380969 | 0.69 | ALDH1A1 (0.43) | KDM4E | |
| SCHEMBL19361418 | 0.67 | ALDH1A1 (0.49) | — | |
| Formaldehyde SCHEMBL28437274 | 0.66 | ALDH1A1 (0.48) | KDM4E | |
| SCHEMBL12601548 | 0.66 | PKM (0.58) | KDM4E | |
| SCHEMBL19199222 | 0.65 | TERT (0.44) | ADORA3ADORA2AADORA2BADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128388-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-05-08 | — | — | US | disclosed |
| US-8541415-B2 | Targeting an HIV-1 nef-host cell kinase complex | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-09-24 | — | — | US | disclosed |
| US-20110190241-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERISTY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190241-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | HCK, DCK, NCK1 | ADORA3 3554/4885ADORA2A 3873/4885ADORA2B 4617/4885 |
| US-20140128388-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | HCK, DCK, NCK1 | ADORA3 3520/4885ADORA2A 3835/4885ADORA2B 4614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.