Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ABHD10 | Q9NUJ1 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18052993 | 0.86 | BCHE (0.33) | ECE1BCHEHPGD | |
| SCHEMBL18052958 | 0.84 | NOTUM (0.38) | ACACBTP53LMNAFFAR4HPGD | |
| SCHEMBL20224080 | 0.83 | ECE1 (0.31) | GPR119ECE1BCHE | |
| SCHEMBL23397291 | 0.81 | PTGS2 (0.33) | ACACBGPR119PTGS2BCHEPOLB | |
| SCHEMBL18054201 | 0.78 | CYP19A1 (0.37) | LMNAFFAR4JMJD6 | |
| SCHEMBL18054137 | 0.77 | PTGS2 (0.35) | GPR119PTGS2LMNABRD4PTGS1 | |
| SCHEMBL20977762 | 0.77 | ACACB (0.36) | ACACBGPR119S1PR3PTGS2BCHE | |
| SCHEMBL20224097 | 0.75 | L3MBTL1 (0.34) | POLBLMNAJMJD6 | |
| SCHEMBL20227221 | 0.74 | NOTUM (0.38) | S1PR3POLBTP53HPGDBRD4 | |
| SCHEMBL18052988 | 0.73 | PTGER4 (0.35) | ACACBFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261637-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2021-05-26 | — | — | EP | disclosed |