Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ABHD10 | Q9NUJ1 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18054331 | 0.87 | NPSR1 (0.39) | HTTLMNAPOLBL3MBTL1TSHR | |
| SCHEMBL18054225 | 0.86 | BCHE (0.34) | GPR119HTTLMNAL3MBTL1KMT2A | |
| SCHEMBL20224103 | 0.82 | NOTUM (0.33) | BCHE | |
| SCHEMBL18054133 | 0.82 | ELANE (0.34) | HTTLMNAPOLBTSHRKDM4E | |
| SCHEMBL20977762 | 0.81 | ACACB (0.36) | PTGS2PTGS1GPR119HTTLMNA | |
| SCHEMBL23397289 | 0.81 | ACACB (0.36) | PTGS2PTGS1GPR119LMNAPOLB | |
| SCHEMBL18054356 | 0.78 | KDR (0.35) | PTGS2PTGS1GPR119HTTLMNA | |
| SCHEMBL18054137 | 0.77 | PTGS2 (0.35) | PTGS2PTGS1GPR119HTTLMNA | |
| SCHEMBL18052970 | 0.76 | ALDH1A1 (0.39) | LMNAPOLBTSHRKMT2AKDM4E | |
| SCHEMBL20227228 | 0.76 | NOTUM (0.40) | BCHEKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261637-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2021-05-26 | — | — | EP | disclosed |