Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23480711 | 0.86 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2DYRK1ACA2 | |
| SCHEMBL18984451 | 0.84 | SMN1; SMN2 (0.64) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL28247185 | 0.83 | DYRK1A (0.60) | NPC1RAB9ASMN1; SMN2DYRK1APIK3CA | |
| SCHEMBL121976 | 0.83 | RAB9A (0.52) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL6979665 | 0.83 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2LDHAMAPT | |
| SCHEMBL1638828 | 0.81 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL2000313 | 0.81 | NPC1 (0.51) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL13881961 | 0.79 | RAB9A (0.51) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL13412996 | 0.79 | NPC1 (0.49) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL31003225 | 0.79 | RAB9A (0.56) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11484529-B2 | Desmethylanethole trithione derivatives for the treatment of diseases linked to mitochondrial reactive oxygen species (ROS) production | OP2 Drugs (FR) | 2022-11-01 | — | — | US | disclosed |
| US-20210154175-A1 | DESMETHYLANETHOLE TRITHIONE DERIVATIVES FOR THE TREATMENT OF DISEASES LINKED TO MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PRODUCTION | OP2 Drugs (FR) | 2021-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210154175-A1 | DESMETHYLANETHOLE TRITHIONE DERIVATIVES FOR THE TREATMENT OF DISEASES LINKED TO MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PRODUCTION | TXN2, ROS1, ERAL1 | NPC1 1258/4885RAB9A 648/4885CDK5 3682/4885 |
| US-11484529-B2 | Desmethylanethole trithione derivatives for the treatment of diseases linked to mitochondrial reactive oxygen species (ROS) production | TXN2, ROS1, ERAL1 | NPC1 1258/4885RAB9A 648/4885CDK5 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.