Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.88 |
| ▸ | RORC | P51449 | 4/20 | 0.88 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.88 |
| ▸ | USP2 | O75604 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 1/20 | 0.88 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.88 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.88 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.75 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.75 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.75 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.75 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.73 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.71 |
| ▸ | CRYAB | P02511 | 1/20 | 0.71 |
| ▸ | HMGCR | P04035 | 1/20 | 0.71 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.71 |
| ▸ | ITGAV | P06756 | 1/20 | 0.71 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.71 |
| ▸ | POLA1 | P09884 | 1/20 | 0.70 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL8899129 | 1.00 | OSBP (0.88) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL8899126 | 1.00 | OSBP (0.88) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL245456 | 0.95 | OSBP (0.89) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27666236 | 0.95 | OSBP (0.89) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27668883 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29502101 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL1369602 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL30101141 | 0.95 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL25657 | 0.95 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL31090041 | 0.95 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545791-B | Cosmetic preparation | 信越化学工业株式会社 | 2022-12-20 | — | — | CN | disclosed |
| WO-2021105223-A1 | METHODS AND DEVICES FOR PERFORMING AN ANALYTICAL MEASUREMENT | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-03 | — | — | WO | disclosed |
| CN-100581529-C | Care and/or make-up cosmetic composition structured with silicone polymers and organogelators in rigid form | OREAL | 2010-01-20 | — | — | CN | disclosed |