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Cholesterol

Cholesterol

SCHEMBL8899129

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(O)C(=O)O

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1

The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ OSBP P22059 6/20 0.88
▸ RORC P51449 4/20 0.88
▸ OSBP2 Q969R2 3/20 0.88
▸ USP2 O75604 1/20 0.88
▸ LMNA P02545 1/20 0.88
▸ ABCB1 P08183 1/20 0.88
▸ CYP46A1 Q9Y6A2 1/20 0.88
▸ NR1H3 Q13133 9/20 0.75
▸ EPHA2 P29317 1/20 0.75
▸ GRIN1 Q05586 4/20 0.75
▸ GRIN2A Q12879 4/20 0.75
▸ GRIN2B Q13224 3/20 0.73
▸ NPC1L1 Q9UHC9 2/20 0.71
▸ CRYAB P02511 1/20 0.71
▸ HMGCR P04035 1/20 0.71
▸ ITGB3 P05106 1/20 0.71
▸ ITGAV P06756 1/20 0.71
▸ SREBF2 Q12772 1/20 0.71
▸ POLA1 P09884 1/20 0.70
▸ DHCR24 Q15392 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cholesterol SCHEMBL23409665 1.00 OSBP (0.88) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL8899126 1.00 OSBP (0.88) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL245456 0.95 OSBP (0.89) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL27666236 0.95 OSBP (0.89) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL27668883 0.95 OSBP (0.93) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL29502101 0.95 OSBP (0.93) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL1369602 0.95 OSBP (0.93) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL30101141 0.95 OSBP (0.91) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL25657 0.95 OSBP (0.91) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL31090041 0.95 OSBP (0.91) OSBPRORCOSBP2USP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110384191-A A kind of preparation method without rouge without cholesterol sour milk beverage fermented using egg white 浙江大学 2019-10-29 — — CN disclosed
CN-104430851-B A kind of norcholesterol acidified milk and preparation method thereof 广东燕塘乳业股份有限公司 2017-08-25 — — CN disclosed
CN-102899276-B Streptococcus thermophilus capable of lowering cholesterol levels and application thereof SHANDONG BOLY LELY BIOENGINEERING CO LTD 2014-06-04 — — CN disclosed
CN-102899276-A Streptococcus thermophilus capable of lowering cholesterol levels and application thereof SHANDONG BOLY LELY BIOENGINEERING CO LTD 2013-01-30 — — CN disclosed
EP-0654659-B1 Defined volume test device BOEHRINGER MANNHEIM CORP (US) 1997-02-12 — — EP disclosed
EP-0345781-B1 Defined volume test device BOEHRINGER MANNHEIM CORP (US) 1995-08-30 — — EP disclosed
EP-0654659-A1 Defined volume test device BOEHRINGER MANNHEIM CORPORATION (US) 1995-05-24 — — EP disclosed
US-4994238-A Constant volume chemical analysis test device ROCHE DIABETES CARE, INC. 1991-02-19 — — US disclosed
EP-0345781-A2 Defined volume test device BOEHRINGER MANNHEIM CORPORATION (US) 1989-12-13 — — EP disclosed