Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | KHK | P50053 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485421 | 0.91 | ADRB1 (0.61) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL23412145 | 0.91 | ADRB1 (0.61) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| Hydrochloric Acid SCHEMBL23411807 | 0.90 | ADRB1 (0.59) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| Hydrochloric Acid SCHEMBL23411806 | 0.89 | HTR3E (0.58) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL1556724 | 0.84 | CHRNB2 (0.61) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL20842185 | 0.84 | CYP2D6 (0.60) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL1426558 | 0.82 | CYP2D6 (0.61) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL20455740 | 0.81 | CYP2D6 (0.60) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL1426810 | 0.80 | CYP2D6 (0.82) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL5389142 | 0.80 | CHRNB2 (0.57) | USP2ALDH1A1CYP3A4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250188057-A1 | NON-AROMATIC CYCLIC-PYRIMIDINE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-06-12 | — | — | US | disclosed |
| EP-4490148-A2 | NON-AROMATIC CYCLIC-PYRIMIDINE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023172475-A2 | NON-AROMATIC CYCLIC-PYRIMIDINE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-09-14 | — | — | WO | disclosed |
| US-20200048267-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-13 | — | — | US | disclosed |
| WO-2018141984-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2018-08-09 | — | — | WO | disclosed |
| WO-2013066729-A1 | AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-05-10 | — | — | WO | disclosed |
| EP-2301936-A1 | SPIRODIAMINE-DIARYLKETOXIME DERIVATIVE | Banyu Pharmaceutical Co., Ltd. (JP) | 2011-03-30 | — | — | EP | disclosed |
| US-20110071129-A1 | SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE | MSD K.K. (JP) | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071129-A1 | SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE | MCHR2, MCHR1, ADRB2 | USP2 3091/4885ALDH1A1 409/4885CYP3A4 251/4885 |
| US-20200048267-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | USP2 705/4885ALDH1A1 3839/4885CYP3A4 4278/4885 |
| US-20250188057-A1 | NON-AROMATIC CYCLIC-PYRIMIDINE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GBA1, GBA2, ASAH2 | USP2 2982/4885ALDH1A1 1841/4885CYP3A4 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.