Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15641907 | 0.78 | ALDH1A1 (0.43) | HSD17B10NPSR1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL248683 | 0.77 | ELANE (0.50) | HSD17B10ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL236001 | 0.74 | ALDH1A1 (0.33) | ALDH1A1POLB | |
| SCHEMBL26779179 | 0.74 | GAA (0.46) | NPSR1ALDH1A1HPGDSMN1; SMN2PKM | |
| SCHEMBL20850459 | 0.74 | CA12 (0.67) | HSD17B10NPSR1ALDH1A1HPGDCA12 | |
| SCHEMBL2045329 | 0.73 | NPSR1 (0.68) | HSD17B10NPSR1ALDH1A1HPGDCA12 | |
| SCHEMBL2041332 | 0.73 | NPSR1 (0.68) | HSD17B10NPSR1ALDH1A1HPGDCA12 | |
| SCHEMBL2460687 | 0.72 | NPC1 (0.57) | HSD17B10ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL3680113 | 0.71 | POLB (0.41) | ALDH1A1RAB9ASMN1; SMN2PKMCYP2D6 | |
| SCHEMBL2045132 | 0.71 | ALDH1A1 (0.60) | HSD17B10NPSR1ALDH1A1HPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8623627-B2 | Labelling of fusion proteins with synthetic probes | NEW ENGLAND BIOLABS, INC (US) | 2014-01-07 | — | — | US | disclosed |
| US-20130130291-A1 | Labelling of Fusion Proteins with Synthetic Probes | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2013-05-23 | — | — | US | disclosed |
| EP-2049499-B1 | LABELLING OF FUSION PROTEINS WITH SYNTHETIC PROBES | EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2012-10-31 | — | — | EP | disclosed |
| US-20120237961-A1 | Labelling of Fusion Proteins with Synthetic Probes | GAUTIER ARNAUD (CH) | 2012-09-20 | — | — | US | disclosed |
| US-8227602-B2 | Labelling of fusion proteins with synthetic probes | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2012-07-24 | — | — | US | disclosed |
| US-20110207157-A1 | Labelling of Fusion Proteins With Synthetic Probes | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2011-08-25 | — | — | US | disclosed |
| EP-2049499-A1 | LABELLING OF FUSION PROTEINS WITH SYNTHETIC PROBES | EPFL Ecole Polytechnique Fédérale de Lausanne (CH) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008012296-A1 | LABELLING OF FUSION PROTEINS WITH SYNTHETIC PROBES | EPFL - ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207157-A1 | Labelling of Fusion Proteins With Synthetic Probes | GART, ALKBH2, ATIC | HSD17B10 2999/4885NPSR1 4034/4885ALDH1A1 1692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.