Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 16/20 | 0.71 |
| ▸ | LONP1 | P36776 | 12/20 | 0.71 |
| ▸ | PSMB8 | P28062 | 11/20 | 0.71 |
| ▸ | PSMB9 | P28065 | 11/20 | 0.71 |
| ▸ | PSMB6 | P28072 | 11/20 | 0.71 |
| ▸ | PSMB10 | P40306 | 11/20 | 0.71 |
| ▸ | PSMB11 | A5LHX3 | 10/20 | 0.71 |
| ▸ | PSMA7 | O14818 | 10/20 | 0.71 |
| ▸ | PSMB1 | P20618 | 10/20 | 0.71 |
| ▸ | PSMA1 | P25786 | 10/20 | 0.71 |
| ▸ | PSMA2 | P25787 | 10/20 | 0.71 |
| ▸ | PSMA3 | P25788 | 10/20 | 0.71 |
| ▸ | PSMA4 | P25789 | 10/20 | 0.71 |
| ▸ | PSMA5 | P28066 | 10/20 | 0.71 |
| ▸ | PSMB4 | P28070 | 10/20 | 0.71 |
| ▸ | PSMB3 | P49720 | 10/20 | 0.71 |
| ▸ | PSMB2 | P49721 | 10/20 | 0.71 |
| ▸ | PSMA6 | P60900 | 10/20 | 0.71 |
| ▸ | PSMA8 | Q8TAA3 | 10/20 | 0.71 |
| ▸ | PSMB7 | Q99436 | 10/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL2931152 | 0.90 | PSMB5 (0.68) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL28490857 | 0.90 | PSMB5 (0.68) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL19712512 | 0.89 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL1406108 | 0.89 | PSMB5 (0.66) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| SCHEMBL7211174 | 0.89 | PSMB5 (0.70) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Bortezomib SCHEMBL28091384 | 0.87 | PSMB5 (0.94) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| D-Leucine SCHEMBL2338392 | 0.86 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL1041561 | 0.86 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL2336540 | 0.86 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 | |
| Leucine SCHEMBL21955431 | 0.86 | PSMB5 (0.63) | PSMB5LONP1PSMB8PSMB9PSMB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 427 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3078667-B1 | FORMULATION OF BORONIC ACID COMPOUNDS | THE UNITED STATES OF AMERICA REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES (US) | 2018-11-21 | — | — | EP | claimed |
| EP-3078667-A1 | FORMULATION OF BORONIC ACID COMPOUNDS | The United States of America, represented by the Secretary, Department of Health and Human Services (US) | 2016-10-12 | — | — | EP | claimed |
| EP-2251344-B1 | FORMULATION OF BORONIC ACID COMPOUNDS | US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) | 2016-03-30 | — | — | EP | claimed |
| US-20150290277-A1 | PHARMACEUTICAL COMPOSITION | SUN PHARMA ADVANCED RES CO LTD (IN) | 2015-10-15 | — | — | US | claimed |
| US-9095514-B2 | Pharmaceutical composition | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2015-08-04 | — | — | US | claimed |
| US-20150072942-A1 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-03-12 | — | — | US | claimed |
| US-20110275597-A1 | PHARMACEUTICAL COMPOSITION | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2011-11-10 | — | — | US | claimed |
| EP-2379077-A2 | PHARMACEUTICAL COMPOSITION | Sun Pharma Advanced Research Company Limited (IN) | 2011-10-26 | — | — | EP | claimed |
| EP-1355910-B1 | FORMULATION OF BORONIC ACID COMPOUNDS | US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) | 2011-03-09 | — | — | EP | claimed |
| EP-2251344-A1 | Formulation of boronic acid compounds | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-17 | — | — | EP | claimed |
| US-6297217-B1 | TREATMENT OF CANCER WITH PROTEASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | claimed |
| US-6271199-B2 | Treatment of infarcts | MILLENNIUM PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | claimed |
| US-20010002391-A1 | TREATMENT OF INFARCTS | PROSCRIPT, INC. | 2001-05-31 | — | — | US | claimed |
| US-6083903-A | REDUCE RATE OF DEGRADATION OF PROTEINS IN ANIMAL | LEUKOSITE, INC. (US) | 2000-07-04 | — | — | US | claimed |
| EP-0979096-A1 | TREATMENT OF INFARCTS THROUGH INHIBITION OF NF-KAPPAB | PROSCRIPT, INC. (US) | 2000-02-16 | — | — | EP | claimed |
| WO-1998035691-A1 | TREATMENT OF INFARCTS THROUGH INHIBITION OF NF-KAPPAB | PROSCRIPT, INC. (US) | 1998-08-20 | — | — | WO | claimed |
| US-5780454-A | Boronic ester and acid compounds | PROSCRIPT, INC. (US) | 1998-07-14 | — | — | US | claimed |
| EP-0788360-A4 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | PROSCRIPT INC (US) | 1998-05-06 | — | — | EP | claimed |
| EP-0788360-A1 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | PROSCRIPT, INC. (US) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013266-A1 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | PROSCRIPT, INC. (US) | 1996-05-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275597-A1 | PHARMACEUTICAL COMPOSITION | BCAT2, TTR, BCAT1 | PSMB5 52/4885LONP1 1651/4885PSMB8 1639/4885 |
| US-20150290277-A1 | PHARMACEUTICAL COMPOSITION | BCAT2, TTR, BCAT1 | PSMB5 52/4885LONP1 1651/4885PSMB8 1639/4885 |
| US-20150072942-A1 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | BCL6, BCAP31, CD79B | PSMB5 2158/4885LONP1 1638/4885PSMB8 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.