Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9843925 | 0.84 | MTOR (0.48) | NPSR1TEAD4LMNAGAAL3MBTL1 | |
| SCHEMBL13164341 | 0.82 | LMNA (0.53) | NPSR1TEAD4ACHETACR1LMNA | |
| SCHEMBL23429176 | 0.82 | SLC6A9 (0.43) | ACP3EPHX1SLC6A9SLC6A5HSD17B2 | |
| SCHEMBL17586585 | 0.80 | NPSR1 (0.42) | ACP3EPHX1NPSR1HSD17B2LMNA | |
| SCHEMBL17065061 | 0.80 | KDM4E (0.40) | TEAD4TACR1LMNAGAAL3MBTL1 | |
| SCHEMBL31067577 | 0.80 | KDM4E (0.40) | TEAD4TACR1LMNAGAAL3MBTL1 | |
| SCHEMBL25628030 | 0.79 | ACHE (0.44) | ACP3EPHX1ACHEGPR139 | |
| SCHEMBL21600873 | 0.79 | ACHE (0.44) | ACP3EPHX1ACHEGPR139 | |
| SCHEMBL23429097 | 0.78 | GAA (0.50) | ACP3SLC6A9SLC6A5HSD17B2GAA | |
| SCHEMBL25665861 | 0.78 | GAA (0.50) | ACP3SLC6A9SLC6A5HSD17B2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4180424-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2023-05-17 | — | — | EP | disclosed |
| EP-3828173-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |