Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31067623 | 0.83 | CPN1 (0.41) | TDP1MEN1KMT2ALMNATRPA1 | |
| SCHEMBL18604835 | 0.83 | CPN1 (0.41) | TDP1MEN1KMT2ALMNATRPA1 | |
| SCHEMBL23428932 | 0.82 | SLC6A9 (0.42) | SLC6A9SLC6A5ACP3EPHX1TDP1 | |
| SCHEMBL23429020 | 0.82 | ACP3 (0.45) | SLC6A9SLC6A5ACP3EPHX1HSD17B2 | |
| SCHEMBL18604834 | 0.79 | LDHB (0.41) | TDP1MAPTLMNASLC6A4 | |
| SCHEMBL23429046 | 0.75 | TDP1 (0.43) | SLC6A9SLC6A5ACP3EPHX1TDP1 | |
| SCHEMBL25665915 | 0.74 | ALDH1A1 (0.63) | SLC6A9SLC6A5ACP3TDP1MEN1 | |
| SCHEMBL16131576 | 0.73 | MEN1 (0.52) | MEN1KMT2AALOX12HTTLMNA | |
| SCHEMBL14252638 | 0.72 | USP1 (0.44) | ACP3EPHX1USP1WDR48 | |
| SCHEMBL4273016 | 0.72 | SIGMAR1 (0.63) | ACP3MEN1KMT2AMAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4180424-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2023-05-17 | — | — | EP | disclosed |
| EP-3828173-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |