Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17064969 | 0.83 | KLKB1 (0.39) | CHRM3KLKB1 | |
| SCHEMBL28111098 | 0.79 | ACACB (0.36) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL17064972 | 0.78 | GLA (0.41) | KLKB1 | |
| SCHEMBL25668311 | 0.76 | ADRB1 (0.38) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL17064475 | 0.73 | ADRB1 (0.35) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL22394359 | 0.73 | ADRB1 (0.35) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL28534568 | 0.71 | ALDH1A1 (0.39) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL28938019 | 0.71 | KLKB1 (0.54) | KLKB1 | |
| SCHEMBL17064477 | 0.70 | KLKB1 (0.40) | CHRM3KLKB1 | |
| SCHEMBL17064820 | 0.70 | KLKB1 (0.38) | CHRM3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828173-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |