Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | RXRB | P28702 | 1/20 | 0.57 |
| ▸ | RXRG | P48443 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20222901 | 0.86 | RAB9A (0.54) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL3020985 | 0.85 | MAPK1 (0.53) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL8015222 | 0.84 | L3MBTL1 (0.57) | SMN1; SMN2MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL2871937 | 0.83 | MAPT (0.62) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL13342992 | 0.83 | MAPT (0.59) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL3017821 | 0.82 | NPC1 (0.56) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL26641052 | 0.81 | L3MBTL1 (0.50) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL31441164 | 0.81 | HTT (0.59) | SMN1; SMN2MAPK1NPC1RAB9AKMT2A | |
| Acetic Acid SCHEMBL28238681 | 0.80 | RXRA (0.73) | SMN1; SMN2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL3018134 | 0.80 | NPC1 (0.54) | SMN1; SMN2MAPK1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021108628-A1 | SUBSTITUTED MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT | ALKERMES, INC. (US) | 2021-06-03 | — | — | WO | disclosed |