Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23452102 | 0.92 | FEN1 (0.51) | KDM4ESMN1; SMN2KMT2APTGESERCC5 | |
| SCHEMBL23451952 | 0.91 | FEN1 (0.48) | KDM4ESMN1; SMN2KMT2APTGESERCC5 | |
| SCHEMBL23452125 | 0.89 | LMNA (0.49) | KDM4ESMN1; SMN2KMT2APTGESERCC5 | |
| SCHEMBL23452156 | 0.88 | KMT2A (0.48) | KDM4ESMN1; SMN2KMT2APTGESMAPK8 | |
| SCHEMBL23451957 | 0.82 | GABRG2 (0.46) | KDM4ESMN1; SMN2KMT2AALDH1A1GABRA1 | |
| SCHEMBL23452113 | 0.78 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2KMT2AALDH1A1TDP1 | |
| SCHEMBL23452066 | 0.77 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2KMT2AALDH1A1GABRA1 | |
| SCHEMBL23452094 | 0.75 | NPC1 (0.40) | KDM4ESMN1; SMN2KMT2APTGESALDH1A1 | |
| SCHEMBL23452111 | 0.74 | IKBKB (0.47) | SMN1; SMN2KMT2AALDH1A1HSD17B2GABRA1 | |
| SCHEMBL23452001 | 0.71 | LMNA (0.43) | KDM4ESMN1; SMN2KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306103-B2 | Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY | 2022-04-19 | — | — | US | disclosed |
| US-11306103-B2 | Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY | 2022-04-19 | — | — | US | disclosed |
| US-20210171539-A1 | NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) | 2021-06-10 | — | — | US | disclosed |
| US-20210171539-A1 | NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210171539-A1 | NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF | BRD4, BRPF3, AFF4 | KDM4E 125/4885SMN1; SMN2 4333/4885KMT2A 523/4885 |
| US-11306103-B2 | Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof | BRD4, BRPF3, AFF4 | KDM4E 159/4885SMN1; SMN2 4244/4885KMT2A 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.