SCHEMBL2345370

SCHEMBL2345370

Nc1ccc(Oc2ncccn2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
APAF1 O14727 1/20 1.00
ALDH1A1 P00352 6/20 0.57
SMN1; SMN2 Q16637 4/20 0.57
KDM4E B2RXH2 1/20 0.57
LMNA P02545 1/20 0.57
TDP1 Q9NUW8 2/20 0.56
CYP3A4 P08684 1/20 0.56
TSHR P16473 1/20 0.56
MAOA P21397 2/20 0.54
MAPT P10636 3/20 0.50
MITF O75030 1/20 0.50
GAA P10253 1/20 0.50
GFER P55789 1/20 0.50
NLRP1 Q9C000 1/20 0.50
NOD2 Q9HC29 1/20 0.50
RAB9A P51151 2/20 0.48
TEAD4 Q15561 1/20 0.46
MAOB P27338 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24270327 0.80 MEN1 (0.67) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL5586071 0.80 MEN1 (0.67) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL28840343 0.79 MEN1 (0.65) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL6677981 0.78 ALDH1A1 (0.65) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL667594 0.78 MEN1 (0.64) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL5686801 0.77 MEN1 (0.63) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL806523 0.77 MEN1 (0.63) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL22010907 0.77 MEN1 (0.63) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL6943230 0.77 MEN1 (0.63) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2
SCHEMBL1748538 0.77 MEN1 (0.63) MEN1KMT2AAPAF1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230278965-A1 NOVEL CARBONOHYDRAZONOYL DICYANIDE COMPOUNDS COMPRISING 2 OR MORE ARYL OR HETEROARYL CONNECTED VIA LINKER AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2023-09-07 US disclosed
EP-4169916-A1 CARBONOHYDRAZONOYL DICYANIDE COMPOUND INCLUDING AT LEAST TWO TYPES OF ARYL OR HETEROARYL LINKED BY NOVEL LINKER, AND USE THEREOF Korea Institute of Science and Technology (KR) 2023-04-26 EP disclosed
CN-115955968-A Carbohydrazone acyldinitrile compounds comprising at least two aryl or heteroaryl groups connected by a novel linker and uses thereof 韩国科学技术研究院 2023-04-11 CN disclosed
US-11289238-B2 Compositions for the filling of high aspect ratio vertical interconnect access (VIA) holes HERAEUS PRECIOUS METALS NORTH AMERICA CONSHOHOCKEN LLC (US) 2022-03-29 US disclosed
WO-2021256902-A1 CARBONOHYDRAZONOYL DICYANIDE COMPOUND INCLUDING AT LEAST TWO TYPES OF ARYL OR HETEROARYL LINKED BY NOVEL LINKER, AND USE THEREOF 한국과학기술연구원 2021-12-23 WO disclosed
US-20210371375-A1 hTERT MODULATORS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-12-02 US disclosed
WO-2021112933-A1 COMPOSITIONS FOR THE FILLING OF HIGH ASPECT RATIO VERTICAL INTERCONNECT ACCESS (VIA) HOLES HERAEUS PRECIOUS METALS NORTH AMERICA CONSHOHOCKEN LLC (US) 2021-06-10 WO disclosed
US-20210174983-A1 COMPOSITIONS FOR THE FILLING OF HIGH ASPECT RATIO VERTICAL INTERCONNECT ACCESS (VIA) HOLES HERAEUS PRECIOUS METALS NORTH AMERICA CONSHOHOCKEN LLC 2021-06-10 US disclosed
US-20200361860-A1 hTERT MODULATORS AND METHODS OF USE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2020-11-19 US disclosed
US-10556860-B2 hTERT modulators and methods of use ARIZONA BOARD OF REGENTS (US) 2020-02-11 US disclosed
US-4898608-A Pyridylthio-acylanilide herbicides BAYER AKTIENGESELLSCHAFT (DE) 1990-02-06 US disclosed
US-4847258-A MITICIDES CIBA-GEIGY CORPORATION (US) 1989-07-11 US disclosed
US-4797146-A INSECTICIDES, FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1989-01-10 US disclosed
US-4765824-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1988-08-23 US disclosed
US-4753940-A PARASITICIDE, ANTHELMINTIC CIBA-GEIGY CORPORATION (US) 1988-06-28 US disclosed
EP-0229283-A1 Anilides of pyrimidyl-thio-carboxylic acids BAYER AG (DE) 1987-07-22 EP disclosed
EP-0226885-A1 Pyrimidylmercapto-acylanilides BAYER AG (DE) 1987-07-01 EP disclosed
US-4627871-A Herbicidal 2-[4-substituted carboxyamino-phenoxy (or phenyl mercapto)]-substituted pyrimidines BAYER AKTIENGESELLSCHAFT (DE) 1986-12-09 US disclosed
EP-0191474-A1 Barbituric-acid derivatives CIBA-GEIGY AG (CH) 1986-08-20 EP disclosed
EP-0168608-A2 Substituted carboxylic-acid anilides BAYER AG (DE) 1986-01-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200361860-A1 hTERT MODULATORS AND METHODS OF USE TERT, TERF2, RB1 MEN1 1334/4885KMT2A 211/4885APAF1 560/4885
US-10556860-B2 hTERT modulators and methods of use TERT, POT1, TERF2 MEN1 1731/4885KMT2A 606/4885APAF1 1371/4885
US-20230278965-A1 NOVEL CARBONOHYDRAZONOYL DICYANIDE COMPOUNDS COMPRISING 2 OR MORE ARYL OR HETEROARYL CONNECTED VIA LINKER AND USE THEREOF AADAC, CBR3, MTCL3 MEN1 1484/4885KMT2A 929/4885APAF1 3874/4885
US-20210371375-A1 hTERT MODULATORS AND METHODS OF USE TERT, TERF2, RB1 MEN1 1581/4885KMT2A 195/4885APAF1 1377/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.