Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.78 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.78 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.78 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.78 |
| ▸ | APAF1 | O14727 | 2/20 | 0.78 |
| ▸ | NSD2 | O96028 | 2/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.66 |
| ▸ | TDP2 | O95551 | 1/20 | 0.63 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.63 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.63 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23788289 | 0.88 | CASP3 (0.68) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL679695 | 0.88 | CASP3 (1.00) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL23458036 | 0.88 | CASP3 (0.76) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL29412940 | 0.88 | CASP3 (1.00) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7995165 | 0.86 | CASP3 (0.60) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL21690569 | 0.86 | CASP3 (0.77) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL21690572 | 0.84 | CASP3 (0.79) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL23457757 | 0.84 | CASP3 (0.78) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL23457440 | 0.84 | CASP3 (0.74) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL23457859 | 0.82 | CASP3 (0.70) | CASP3SENP6SENP8SENP7APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163453-A1 | DERIVATIVES OF PAPAVERINE THAT ARE EFFECTIVE HYPOXIC TUMOR RADIOSENSITIZERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163453-A1 | DERIVATIVES OF PAPAVERINE THAT ARE EFFECTIVE HYPOXIC TUMOR RADIOSENSITIZERS | HIF1AN, HIF1A, HYOU1 | CASP3 804/4885SENP6 3729/4885SENP8 4029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.