Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2346037 | 0.80 | CDK5 (0.50) | DRD2DRD3HTR6CDK5DYRK1A | |
| SCHEMBL30843943 | 0.80 | CDK5 (0.50) | DRD2DRD3HTR6CDK5DYRK1A | |
| SCHEMBL30775367 | 0.78 | L3MBTL1 (0.52) | DRD2CDK5DYRK1ACLK4PIM1 | |
| SCHEMBL2348607 | 0.75 | DRD2 (0.46) | DRD2DRD3HTR6HRH3CHRNA7 | |
| SCHEMBL12219092 | 0.71 | CDK5 (0.58) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| Hydrochloric Acid SCHEMBL11198122 | 0.70 | DRD2 (0.55) | DRD2DRD3HTR6HRH3HTR2A | |
| SCHEMBL21744256 | 0.69 | DRD2 (0.47) | DRD2DRD3HTR6HRH3CHRNA7 | |
| SCHEMBL11096500 | 0.69 | CHRNA7 (0.59) | DRD2DRD3HTR6HRH3CHRNA7 | |
| SCHEMBL5201380 | 0.69 | DRD3 (0.54) | DRD2DRD3HTR6HRH3 | |
| SCHEMBL29698264 | 0.68 | PARP1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445514-B2 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-05-21 | — | — | US | disclosed |
| US-20110269768-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | KINNEY WILLIAM A | 2011-11-03 | — | — | US | disclosed |
| US-8008299-B2 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (FR) | 2011-08-30 | — | — | US | disclosed |
| US-20080318973-A1 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269768-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | UTS2R, BDKRB2, AGTR2 | DRD2 581/4885DRD3 1250/4885HTR6 830/4885 |
| US-20080318973-A1 | Urotensin II receptor antagonists | UTS2R, BDKRB2, AGTR2 | DRD2 581/4885DRD3 1250/4885HTR6 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.