Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A3 | P48764 | 11/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24201229 | 0.76 | SLC9A3 (0.48) | SLC9A3 | |
| SCHEMBL20404624 | 0.75 | SLC9A3 (0.36) | SLC9A3TUBB1 | |
| SCHEMBL2595393 | 0.74 | LTA4H (0.37) | SLC9A3TUBB1 | |
| SCHEMBL24201173 | 0.73 | LTA4H (0.33) | SLC9A3 | |
| SCHEMBL24201220 | 0.72 | SLC9A3 (0.36) | SLC9A3 | |
| SCHEMBL19593632 | 0.72 | SLC9A3 (0.42) | SLC9A3TUBB1 | |
| SCHEMBL17991934 | 0.72 | SLC9A3 (0.57) | SLC9A3 | |
| SCHEMBL19593883 | 0.71 | ESR1 (0.40) | SLC9A3TUBB1 | |
| SCHEMBL19593445 | 0.71 | SLC9A3 (0.41) | SLC9A3TUBB1 | |
| SCHEMBL19593832 | 0.70 | SLC9A3 (0.39) | SLC9A3TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351248-B1 | COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS | ARDELYX INC (US) | 2021-06-09 | — | — | EP | disclosed |