Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472188 | 0.77 | TLR7 (0.36) | TLR7TLR8KCNH2PDE1BPDE1A | |
| SCHEMBL20219780 | 0.72 | CYP11B1 (0.35) | TLR8KCNH2PDE1BPDE1APDE1C | |
| SCHEMBL15469944 | 0.71 | TLR7 (0.43) | TLR7TLR8KCNH2 | |
| SCHEMBL19274182 | 0.71 | TLR7 (0.43) | TLR7TLR8KCNH2 | |
| SCHEMBL20219553 | 0.70 | TLR7 (0.44) | TLR7TLR8KCNH2 | |
| SCHEMBL20219595 | 0.69 | TLR7 (0.40) | TLR7TLR8KCNH2 | |
| SCHEMBL23472393 | 0.67 | TLR7 (0.40) | TLR7TLR8KCNH2 | |
| SCHEMBL17123641 | 0.67 | P2RX3 (0.41) | TLR7TLR8KCNH2ALDH1A1 | |
| SCHEMBL15470279 | 0.67 | TLR7 (0.46) | TLR7TLR8KCNH2 | |
| SCHEMBL23472500 | 0.66 | AOC3 (0.40) | TLR7TLR8KCNH2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |