Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20413303 | 0.82 | TLR7 (0.37) | TLR7TLR8KCNH2LMNA | |
| SCHEMBL13195109 | 0.81 | TLR7 (0.46) | TLR7TLR8KCNH2 | |
| SCHEMBL20219539 | 0.81 | TLR7 (0.46) | TLR7TLR8KCNH2 | |
| SCHEMBL20219573 | 0.79 | TLR7 (0.35) | TLR7TLR8KCNH2LMNA | |
| SCHEMBL23472229 | 0.77 | TLR7 (0.34) | TLR7TLR8PDE1BPDE1APDE1C | |
| SCHEMBL20219780 | 0.72 | CYP11B1 (0.35) | TLR8PDE1BPDE1APDE1CKCNH2 | |
| SCHEMBL20219595 | 0.72 | TLR7 (0.40) | TLR7TLR8KCNH2 | |
| SCHEMBL26551525 | 0.72 | LMNA (0.46) | CYP3A4CYP1A2HSD17B10ALDH1A1TDP1 | |
| SCHEMBL20219582 | 0.69 | TLR8 (0.45) | TLR7TLR8KCNH2CYP1A2 | |
| SCHEMBL23472389 | 0.69 | KCNH2 (0.47) | TLR7TLR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |