Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.40 |
| ▸ | PTGES | O14684 | 7/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219393 | 0.95 | TLR8 (0.38) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL23472598 | 0.91 | TLR8 (0.43) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL23472561 | 0.89 | TLR8 (0.48) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL20219279 | 0.84 | TLR8 (0.35) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL23472079 | 0.84 | TLR8 (0.47) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL20219252 | 0.81 | CXCR2 (0.42) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL23472304 | 0.80 | CTSK (0.38) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL20219329 | 0.79 | SIGMAR1 (0.41) | PPARGPTGESALOX5TLR8TLR7 | |
| SCHEMBL23472323 | 0.78 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL20219257 | 0.78 | SIGMAR1 (0.41) | PPARGPTGESALOX5TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |