Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2353150 | 0.81 | SIGMAR1 (0.39) | ALDH1A1MEN1HPGDHTTKMT2A | |
| SCHEMBL4084447 | 0.79 | LMNA (0.48) | ALDH1A1MEN1HTTKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL4081730 | 0.77 | LMNA (0.47) | ALDH1A1MEN1HTTKMT2ALMNA | |
| Bromide SCHEMBL27643550 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MEN1HPGDHTTKMT2A | |
| SCHEMBL27624228 | 0.73 | ALDH1A1 (0.41) | ALDH1A1MEN1HPGDHTTKMT2A | |
| SCHEMBL28598923 | 0.66 | TSHR (0.50) | ALDH1A1TSHRLMNACYP2C19 | |
| SCHEMBL28946773 | 0.66 | POLB (0.50) | ALDH1A1MEN1KMT2ALMNAPOLB | |
| SCHEMBL13386604 | 0.65 | ALDH1A1 (0.55) | ALDH1A1TSHR | |
| SCHEMBL28062275 | 0.65 | MC4R (0.43) | ALDH1A1MEN1HTTKMT2ALMNA | |
| Bromide SCHEMBL1046939 | 0.64 | BRD4 (0.50) | MEN1HTTKMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1576039-B1 | CATALYTIC DEPOLYMERIZATION OF POLYMERS CONTAINING ELECTROPHILIC LINKAGES USING NUCLEOPHILIC REAGENTS | IBM (US) | 2011-08-03 | — | — | EP | disclosed |
| US-7544800-B2 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2009-06-09 | — | — | US | disclosed |
| US-7053221-B2 | Heteroatom-stabilized carbenes and precursors thereto as depolymerization catalysts | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2006-05-30 | — | — | US | disclosed |
| US-20050288508-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2005-12-29 | — | — | US | disclosed |
| US-6916936-B2 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2005-07-12 | — | — | US | disclosed |
| US-6911546-B2 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2005-06-28 | — | — | US | disclosed |
| US-20050049418-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | HEDRICK JAMES LUPTON (US) | 2005-03-03 | — | — | US | disclosed |
| US-20040127720-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | NATIONAL SCIENCE FOUNDATION | 2004-07-01 | — | — | US | disclosed |
| US-20040127744-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | NATIONAL SCIENCE FOUNDATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288508-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | POLL, PNKP, PARN | ALDH1A1 3878/4885TSHR 4334/4885MEN1 3011/4885 |
| US-20050049418-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | POLL, PNKP, PARN | ALDH1A1 3878/4885TSHR 4334/4885MEN1 3011/4885 |
| US-20040127744-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | POLL, PNKP, PARP1 | ALDH1A1 3798/4885TSHR 4327/4885MEN1 3037/4885 |
| US-20040127720-A1 | Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents | POLL, PNKP, PARP1 | ALDH1A1 3798/4885TSHR 4327/4885MEN1 3037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.