Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17424339 | 0.92 | ALDH1A1 (0.70) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL2342014 | 0.89 | ALDH1A1 (0.72) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL2349534 | 0.88 | ALDH1A1 (0.82) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL7303587 | 0.86 | RAB9A (0.68) | ALDH1A1MEN1KMT2ANPC1SERPINE1 | |
| SCHEMBL15149738 | 0.85 | SERPINE1 (0.53) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL2343610 | 0.84 | NPC1 (0.74) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL29661130 | 0.84 | NPC1 (0.74) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL2347427 | 0.83 | ALDH1A1 (0.61) | EPHX1ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL28330746 | 0.82 | PLK1 (0.52) | ALDH1A1CYP1A2MEN1KMT2ANPC1 | |
| SCHEMBL2347474 | 0.81 | EPHX2 (0.56) | EPHX1ALDH1A1CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | claimed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | claimed |
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | SIGA TECHNOLOGIES INC. (US) | 2013-08-01 | — | — | US | claimed |
| EP-2536286-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | Siga Technologies, Inc. (US) | 2012-12-26 | — | — | EP | claimed |
| WO-2011103375-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2011-08-25 | — | — | WO | claimed |
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9968571-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | disclosed |
| US-9566254-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| US-20160081950-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160081950-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160081950-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2016-03-24 | — | — | US | disclosed |
| US-9233087-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233087-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233087-B2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | SIGA TECHNOLOGIES, INC (US) | 2016-01-12 | — | — | US | disclosed |
| EP-2865668-A2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | Siga Technologies, Inc. (US) | 2015-04-29 | — | — | EP | disclosed |
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | SIGA TECHNOLOGIES INC. (US) | 2013-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | TST, TPMT, EIF2AK2 | EPHX1 3446/4885ALDH1A1 3069/4885CYP1A2 4529/4885 |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | TST, TPMT, EIF2AK2 | EPHX1 3446/4885ALDH1A1 3069/4885CYP1A2 4529/4885 |
| US-20160081950-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | TST, TPMT, EIF2AK2 | EPHX1 3446/4885ALDH1A1 3069/4885CYP1A2 4529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.