Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.60 |
| ▸ | CTSG | P08311 | 2/20 | 0.55 |
| ▸ | CMA1 | P23946 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | PAM | P19021 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995229 | 0.87 | ALDH1A1 (0.64) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL6293500 | 0.87 | ALDH1A1 (0.64) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL995228 | 0.87 | ALDH1A1 (0.64) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL14611741 | 0.85 | CTSL (0.65) | ALDH1A1POLBCTSSCTSLCTSB | |
| SCHEMBL16473192 | 0.85 | ALDH1A1 (0.60) | ALDH1A1POLBCTSSCTSLCTSB | |
| SCHEMBL20468445 | 0.85 | ALDH1A1 (0.60) | ALDH1A1POLBCTSSCTSLCTSB | |
| SCHEMBL25003472 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL8878324 | 0.84 | POLB (0.64) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL2635223 | 0.84 | POLB (0.64) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL12201967 | 0.84 | ALDH1A1 (0.59) | ALDH1A1POLBCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113743-A1 | SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-10 | — | — | WO | disclosed |