Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23491339 | 0.72 | L3MBTL1 (0.41) | L3MBTL1MAPK1HTTROCK2GPR139 | |
| SCHEMBL23491352 | 0.70 | NPC1 (0.48) | L3MBTL1HTTGPR139TP53TDP1 | |
| SCHEMBL23492971 | 0.68 | F2 (0.45) | MASP2F2MAPK1 | |
| SCHEMBL23491362 | 0.68 | F2 (0.44) | MASP2F2MAPK1MTNR1AMTNR1B | |
| SCHEMBL16128275 | 0.63 | TAAR1 (0.53) | HTTTDP1MEN1KMT2ANPC1 | |
| SCHEMBL23493002 | 0.62 | BCHE (0.47) | L3MBTL1MAPK1MEN1KMT2ARAB9A | |
| SCHEMBL23452293 | 0.62 | RHEB (0.47) | MASP2F2POLB | |
| SCHEMBL25054045 | 0.62 | NPC1 (0.47) | L3MBTL1HTTGPR139TDP1MEN1 | |
| SCHEMBL23452513 | 0.59 | MASP2 (0.34) | MASP2F2 | |
| SCHEMBL23478648 | 0.59 | LOXL2 (0.39) | MASP2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113682-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION (US) | 2021-06-10 | — | — | WO | disclosed |