Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.83 |
| ▸ | MEN1 | O00255 | 5/20 | 0.83 |
| ▸ | RAB9A | P51151 | 11/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.81 |
| ▸ | NPC1 | O15118 | 10/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.78 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | HTR1D | P28221 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2346876 | 0.89 | KMT2A (0.83) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL13856442 | 0.88 | MAPT (1.00) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12345548 | 0.85 | NPC1 (0.83) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL10090744 | 0.82 | NPC1 (0.78) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL2346117 | 0.82 | RAB9A (0.73) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8985995 | 0.82 | HTR1D (0.74) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL31254451 | 0.81 | RAB9A (1.00) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL6293939 | 0.80 | ROCK2 (0.65) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL18737213 | 0.80 | RAB9A (0.79) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7803371 | 0.78 | HTR1D (1.00) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |
| EP-1940786-B1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LTD (GB) | 2010-08-18 | — | — | EP | disclosed |
| US-20080255105-A1 | Biphenyl Derivatives and Their Use in Treating Hepatitis C | ARROW THERAPEUTICS LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255105-A1 | Biphenyl Derivatives and Their Use in Treating Hepatitis C | NR4A1, NR0B1, NR1H4 | KMT2A 3804/4885MEN1 3163/4885RAB9A 1870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.