Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.78 |
| ▸ | RAB9A | P51151 | 8/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090719 | 0.90 | MAPT (0.79) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL12345548 | 0.86 | NPC1 (0.83) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL18737213 | 0.85 | RAB9A (0.79) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL2349361 | 0.82 | KMT2A (0.83) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL31254451 | 0.81 | RAB9A (1.00) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL28715654 | 0.80 | RAB9A (0.69) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL6293964 | 0.79 | ALDH1A1 (0.67) | POLBALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2346117 | 0.78 | RAB9A (0.73) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL11733136 | 0.78 | ALDH1A1 (0.65) | POLBALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL10090762 | 0.78 | ATM (0.69) | NPC1RAB9APOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11020391-B2 | CRMP2 sumoylation inhibitors and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-06-01 | — | — | US | disclosed |
| US-10441586-B2 | CRMP2 SUMOylation inhibitors and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-10-15 | — | — | US | disclosed |
| WO-2017062804-A1 | CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-04-13 | — | — | WO | disclosed |
| US-20160166553-A1 | ANTIMETASTATIC COMPOUNDS | UNIV BRIGHAM YOUNG (US) | 2016-06-16 | — | — | US | disclosed |
| US-20130158035-A1 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
| WO-2012027392-A2 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158035-A1 | ANTIMETASTATIC COMPOUNDS | MET, HGFAC, HGF | NPC1 1073/4885RAB9A 2160/4885POLB 3043/4885 |
| US-11020391-B2 | CRMP2 sumoylation inhibitors and uses thereof | SUMO2, SUMO1, SUMO3 | NPC1 1991/4885RAB9A 1676/4885POLB 4790/4885 |
| US-20160166553-A1 | ANTIMETASTATIC COMPOUNDS | MET, HGFAC, HGF | NPC1 1073/4885RAB9A 2160/4885POLB 3043/4885 |
| US-10441586-B2 | CRMP2 SUMOylation inhibitors and uses thereof | SUMO1, SUMO2, SUMO3 | NPC1 1542/4885RAB9A 1770/4885POLB 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.