Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621335 | 0.91 | CXCR3 (0.60) | CXCR3LMNAL3MBTL1SIGMAR1DRD4 | |
| Hydrochloric Acid SCHEMBL4891466 | 0.90 | L3MBTL1 (0.60) | CXCR3LMNAL3MBTL1SIGMAR1DRD4 | |
| SCHEMBL14197754 | 0.81 | LMNA (0.60) | CXCR3LMNAL3MBTL1SIGMAR1KDM4E | |
| SCHEMBL938062 | 0.79 | L3MBTL1 (0.57) | LMNAL3MBTL1SIGMAR1DRD4KDM4E | |
| SCHEMBL31653494 | 0.79 | L3MBTL1 (0.57) | LMNAL3MBTL1SIGMAR1DRD4KDM4E | |
| SCHEMBL6397656 | 0.78 | L3MBTL1 (0.56) | LMNAL3MBTL1SIGMAR1DRD4KDM4E | |
| SCHEMBL2033541 | 0.78 | L3MBTL1 (0.56) | LMNAL3MBTL1SIGMAR1DRD4KDM4E | |
| SCHEMBL6399073 | 0.78 | L3MBTL1 (0.56) | LMNAL3MBTL1SIGMAR1DRD4KDM4E | |
| SCHEMBL6397064 | 0.78 | L3MBTL1 (0.59) | LMNAL3MBTL1SIGMAR1DRD4KDM4E | |
| SCHEMBL2032759 | 0.77 | CHRM2 (0.51) | LMNAL3MBTL1SIGMAR1DRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193604-B1 | SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS | EPIZYME INC (US) | 2021-06-16 | — | — | EP | disclosed |