Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211202 | 0.93 | ALDH1A1 (0.40) | HDAC1HDAC2ALDH1A1KDM4EGAA | |
| SCHEMBL19249157 | 0.83 | KDM4A (0.39) | KDM4AKDM4EGAA | |
| SCHEMBL19249205 | 0.80 | CA1 (0.38) | KDM4A | |
| SCHEMBL19249244 | 0.79 | CA2 (0.40) | ALDH1A1KDM4EGAAPDPK1 | |
| SCHEMBL23491567 | 0.77 | HDAC1 (0.41) | HDAC1KDM4AALDH1A1KDM4EGAA | |
| SCHEMBL16837664 | 0.77 | HDAC1 (0.46) | EGFRRAF1KDRMAP2K2MAP2K1 | |
| SCHEMBL19211218 | 0.76 | MEN1 (0.37) | KDM4EGAASMN1; SMN2 | |
| SCHEMBL19248872 | 0.73 | NQO2 (0.43) | KDM4AGAAL3MBTL1CTSKPDPK1 | |
| SCHEMBL19248873 | 0.73 | NQO2 (0.45) | EGFRHDAC1KDM4AGAAPDPK1 | |
| SCHEMBL20721075 | 0.73 | BTK (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414229-B1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2021-06-16 | — | — | EP | disclosed |