Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 4/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249245 | 0.90 | PLA2G2A (0.46) | PLA2G2ADYRK1AKDM4EMAPT | |
| SCHEMBL19248870 | 0.88 | EGLN2 (0.40) | HPGD | |
| SCHEMBL19248872 | 0.87 | NQO2 (0.43) | CA2PLA2G2ADYRK1ACA12CA1 | |
| SCHEMBL23491567 | 0.87 | HDAC1 (0.41) | CA2PLA2G2ADYRK1AKDM4EALDH1A1 | |
| SCHEMBL19211242 | 0.80 | CA2 (0.40) | CA2PLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL23507767 | 0.79 | EGFR (0.39) | PDPK1KDM4EALDH1A1GAA | |
| SCHEMBL19249247 | 0.77 | MMP13 (0.47) | PLA2G2ADYRK1AKDM4EALDH1A1MAPT | |
| SCHEMBL19248874 | 0.76 | EGLN2 (0.42) | PLA2G2AKDM4EALDH1A1GAAMAPT | |
| SCHEMBL20729415 | 0.76 | BCHE (0.43) | PLA2G2ADYRK1AKDM4EALDH1A1MAPT | |
| SCHEMBL19249157 | 0.75 | KDM4A (0.39) | KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139274-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-08-17 | — | — | WO | disclosed |