Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29301807 | 0.81 | DHFR (0.42) | PDE3BPDE3ADHFRSLC2A1KDM4E | |
| SCHEMBL22533671 | 0.78 | DHFR (0.40) | PDE3BPDE3ADHFRSLC2A1MAOA | |
| SCHEMBL17531158 | 0.77 | PDE3B (0.56) | PDE3BPDE3AMAOAKDM4EALDH1A1 | |
| SCHEMBL26144292 | 0.71 | PDE3B (0.50) | PDE3BPDE3AMAOAKDM4EALDH1A1 | |
| SCHEMBL19737437 | 0.70 | DAO (0.50) | PDE3BPDE3ADHFRSLC2A1ALDH1A1 | |
| SCHEMBL17538626 | 0.70 | PDE3B (0.49) | PDE3BPDE3AMAOAKDM4EALDH1A1 | |
| SCHEMBL14327807 | 0.69 | DAO (0.49) | PDE3BPDE3ADHFRSLC2A1MAPT | |
| SCHEMBL10809624 | 0.69 | PDE3B (0.60) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL4394655 | 0.69 | PDE3B (0.51) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL10812608 | 0.69 | PDE3B (0.60) | PDE3BPDE3AMAOAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179612-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179612-A1 | MASP-2 INHIBITORS AND METHODS OF USE | MASP2, METAP2, SPINT2 | PDE3B 2819/4885PDE3A 2618/4885DHFR 4490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.