Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 4/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19120291 | 0.88 | WNT3A (0.37) | WNT3ASOS1KRASLRRK2ACHE | |
| SCHEMBL19120153 | 0.79 | PANK3 (0.42) | WNT3ASOS1KRASLRRK2ACHE | |
| SCHEMBL19148011 | 0.69 | GRIN2D (0.50) | WNT3ASOS1KRASMEN1KMT2A | |
| SCHEMBL22201730 | 0.67 | HRH4 (0.51) | LRRK2MEN1KMT2AHRH4 | |
| SCHEMBL19322639 | 0.67 | MEN1 (0.47) | LRRK2MEN1KMT2APIK3CALMNA | |
| SCHEMBL16019498 | 0.65 | PANK3 (0.48) | MEN1KMT2ALMNAHRH4 | |
| SCHEMBL18235626 | 0.64 | PANK3 (0.44) | WNT3A | |
| SCHEMBL11960332 | 0.64 | LRRK2 (0.43) | SOS1KRASLRRK2HRH4 | |
| SCHEMBL18931264 | 0.64 | PIK3CA (0.51) | LRRK2MEN1KMT2APIK3CAMTOR | |
| SCHEMBL10203431 | 0.63 | HRH4 (0.56) | LRRK2DRD2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179592-A1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179592-A1 | 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | OPRK1, OPRD1, ARRB1 | WNT3A 884/4885SOS1 3175/4885KRAS 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.