SCHEMBL23519084

SCHEMBL23519084

O=C(O)C(F)(F)Oc1cccc(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
RXRG P48443 1/20 0.44
PPARG P37231 4/20 0.44
P2RX1 P51575 1/20 0.44
FFAR1 O14842 1/20 0.44
PPARD Q03181 1/20 0.44
KDM4E B2RXH2 2/20 0.43
OGG1 O15527 1/20 0.42
LMNA P02545 1/20 0.41
NR4A2 P43354 1/20 0.40
PKM P14618 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31421812 1.00 RXRA (0.44) RXRARXRBRXRGPPARGP2RX1
SCHEMBL23519071 0.82 NOTUM (0.47) P2RX1FFAR1
SCHEMBL23519098 0.81 PPARG (0.45) PPARGFFAR1NR4A2
SCHEMBL23519064 0.79 PPARG (0.51) PPARGKDM4ENR4A2
SCHEMBL3374117 0.79 PPARA (0.64) PPARGPPARDKDM4EOGG1PKM
SCHEMBL31433030 0.79 KMT2A (0.46) KDM4ELMNACYP1A2CYP2D6CYP2C9
SCHEMBL23519058 0.79 KAT6A (0.38) PPARGFFAR1NR4A2
SCHEMBL26125657 0.79 LMNA (0.51) PPARGLMNACYP1A2CYP2D6CYP2C19
SCHEMBL17674534 0.79 SSTR4 (0.43) PPARGCYP1A2CYP2D6CYP2C19
SCHEMBL23519083 0.78 PPARA (0.61) PPARGPPARDCYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188037-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES TAKEDA PHARMACEUTICALS CO (JP) 2025-06-12 US disclosed
EP-4499224-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2025-02-05 EP disclosed
WO-2023187677-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-10-05 WO disclosed
US-20210179554-A1 ONIUM SALT COMPOUND, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2021-06-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250188037-A1 N-(PYRROLIDIN-3-YL OR PIPERIDIN-4-YL)ACETAMIDE DERIVATIVES SSTR4, SSTR3, SSTR1 RXRA 1124/4885RXRB 1866/4885RXRG 1436/4885
US-20210179554-A1 ONIUM SALT COMPOUND, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS SLC6A5, LIFR, SLC6A9 RXRA 3630/4885RXRB 3734/4885RXRG 3531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.