SCHEMBL2351992

SCHEMBL2351992

Cn1cc(C(=O)Nc2ccccc2-c2ccc(Cl)c(Cl)c2)c(C(F)(F)F)n1

nearest known ligand 0.55

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.55
POLB P06746 1/20 0.55
CHRM3 P20309 4/20 0.47
NTRK1 P04629 7/20 0.45
STING1 Q86WV6 1/20 0.42
ATM Q13315 1/20 0.42
TRPV1 Q8NER1 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2350381 0.93 LMNA (0.47) LMNAPOLBCHRM3NTRK1ATM
SCHEMBL4914980 0.93 LMNA (0.47) LMNAPOLBCHRM3NTRK1ATM
SCHEMBL14578046 0.89 LMNA (0.68) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL1402183 0.88 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL373929 0.88 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL29445385 0.88 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL29445431 0.88 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL303303 0.88 LMNA (0.53) LMNAPOLBCHRM3NTRK1STING1
SCHEMBL303184 0.88 LMNA (0.58) LMNAPOLBCHRM3NTRK1
SCHEMBL302840 0.88 LMNA (0.60) LMNAPOLBCHRM3NTRK1STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9414600-B2 Active compound combinations BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-08-16 US disclosed
US-8754009-B2 Active compound combinations BAYER CROPSCIENCE AG (DE) 2014-06-17 US disclosed
US-8008232-B2 Such as N-(3',4'-dichlorobiphenyl-2-yl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamide; seeds BASF AKTIENGESELLSCHAFT (DE) 2011-08-30 US disclosed
EP-2279664-A1 Agent combinations Bayer CropScience AG (DE) 2011-02-02 EP disclosed
EP-2272369-A1 Agent combinations Bayer CropScience AG (DE) 2011-01-12 EP disclosed
EP-2272368-A1 Agent combinations Bayer CropScience AG (DE) 2011-01-12 EP disclosed
EP-2269460-A1 Agent combinations Bayer CropScience AG (DE) 2011-01-05 EP disclosed
EP-2263463-A1 Agent combinations Bayer CropScience AG (DE) 2010-12-22 EP disclosed
EP-2263462-A1 Agent combinations Bayer CropScience AG (DE) 2010-12-22 EP disclosed
EP-2260711-A2 Agent combinations Bayer CropScience AG (DE) 2010-12-15 EP disclosed
EP-2255649-A2 Agent combinations Bayer CropScience AG (DE) 2010-12-01 EP disclosed
EP-2255652-A2 Agent combinations Bayer CropScience AG (DE) 2010-12-01 EP disclosed
EP-2255653-A2 Agent combinations Bayer CropScience AG (DE) 2010-12-01 EP disclosed
EP-2253213-A1 Agent combinations Bayer CropScience AG (DE) 2010-11-24 EP disclosed
EP-2253210-A1 Agent combinations Bayer CropScience AG (DE) 2010-11-24 EP disclosed
EP-2253211-A1 Agent combinations Bayer CropScience AG (DE) 2010-11-24 EP disclosed
EP-2253212-A1 Agent combinations Bayer CropScience AG (DE) 2010-11-24 EP disclosed
EP-2132989-A2 Agent combinations Bayer CropScience AG (DE) 2009-12-16 EP disclosed
US-20090036509-A1 N-(Ortho-Phenyl)-1-Methyl -3-Trifluoromethlpyrazole-4-Carboxanilides and Their Use as Fungicides BASF AKTIENGESELLSCHAFT (DE) 2009-02-05 US disclosed
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi BASF AKITENGESELLSCHAFT (DE) 2008-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi CBR3, C1S, PYM1 LMNA 1073/4885POLB 2358/4885CHRM3 222/4885
US-20090036509-A1 N-(Ortho-Phenyl)-1-Methyl -3-Trifluoromethlpyrazole-4-Carboxanilides and Their Use as Fungicides CBR3, CBR1, DDT LMNA 2270/4885POLB 3858/4885CHRM3 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.