SCHEMBL303184

SCHEMBL303184

Cn1cc(C(=O)Nc2ccccc2-c2cccc(Cl)c2)c(C(F)(F)F)n1

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.58
POLB P06746 1/20 0.58
JAK2 O60674 4/20 0.48
JAK1 P23458 1/20 0.48
CHRM3 P20309 4/20 0.47
NTRK1 P04629 4/20 0.45
CYP3A4 P08684 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
ALDH1A1 P00352 1/20 0.43
CHRM1 P11229 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL302840 0.92 LMNA (0.60) LMNAPOLBJAK2JAK1CHRM3
SCHEMBL4171505 0.89 ALDH1A1 (0.55) LMNAPOLBCHRM3NTRK1ALDH1A1
SCHEMBL303104 0.89 LMNA (0.51) LMNAPOLBJAK2JAK1CHRM3
SCHEMBL14578046 0.89 LMNA (0.68) LMNAPOLBCHRM3NTRK1ALDH1A1
SCHEMBL1085471 0.88 LMNA (0.57) LMNAPOLBNTRK1ALDH1A1
SCHEMBL4450835 0.88 LMNA (0.56) LMNAPOLBCHRM3NTRK1
SCHEMBL2351992 0.88 LMNA (0.55) LMNAPOLBCHRM3NTRK1
SCHEMBL4791610 0.87 LMNA (0.54) LMNAPOLBCHRM3NTRK1
SCHEMBL374213 0.87 LMNA (0.56) LMNAPOLBNTRK1
SCHEMBL302426 0.86 LMNA (0.64) LMNAPOLBJAK2JAK1NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2489262-B1 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2018-11-14 EP claimed
US-20150080215-A1 TERNARY PESTICIDAL MIXTURES BASF SE (DE) 2015-03-19 US claimed
US-20140179518-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds BASF SE (DE) 2014-06-26 US claimed
US-20130267414-A1 PESTICIDAL MIXTURES BASF SE (DE) 2013-10-10 US claimed
US-20130137571-A1 Crystalline Modification of Fipronil BASF SE (DE) 2013-05-30 US claimed
EP-2489262-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a fungicide BASF SE (DE) 2012-08-22 EP claimed
EP-2489264-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a carboxamide fungicide BASF SE (DE) 2012-08-22 EP claimed
EP-2489263-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a fungicide BASF SE (DE) 2012-08-22 EP claimed
JP-2012500824-A 2012-01-12 JP claimed
JP-2011527306-A 2011-10-27 JP claimed
EP-2091331-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2009-08-26 EP claimed
WO-2009065834-A2 FUNGICIDAL MIXTURES BASF SE (DE) 2009-05-28 WO claimed
WO-2009062905-A1 PESTICIDAL MIXTURES COMPRISING CYANOSULFOXIMINE COMPOUNDS BASF SE (DE) 2009-05-22 WO claimed
WO-2009063076-A2 FUNGICIDAL MIXTURES III BASF SE (DE) 2009-05-22 WO claimed
WO-2009063074-A2 FUNGICIDAL MIXTURES I BASF SE (DE) 2009-05-22 WO claimed
WO-2009063075-A2 FUNGICIDAL MIXTURES II BASF SE (DE) 2009-05-22 WO claimed
WO-2008148859-A2 FUNGICIDAL MIXTURES BASF SE (DE) 2008-12-11 WO claimed
WO-2008095913-A2 PESTICIDAL MIXTURES BASF SE (DE) 2008-08-14 WO claimed
WO-2008034787-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2008-03-27 WO claimed
WO-2008034785-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2008-03-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130267414-A1 PESTICIDAL MIXTURES AADAC, CTRL, AAAS LMNA 3546/4885POLB 4261/4885JAK2 3540/4885
US-20140179518-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds CPN1, SRM, STS LMNA 3355/4885POLB 3649/4885JAK2 1531/4885
US-20130137571-A1 Crystalline Modification of Fipronil FIP1L1, PTMS, FIBP LMNA 2209/4885POLB 4375/4885JAK2 4698/4885
US-20150080215-A1 TERNARY PESTICIDAL MIXTURES AADAC, AS3MT, DDT LMNA 4360/4885POLB 4562/4885JAK2 2618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.