Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23526323 | 1.00 | HTT (0.46) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL30014041 | 1.00 | HTT (0.46) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL29945834 | 0.82 | HTT (0.41) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL26457642 | 0.82 | HTT (0.41) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL28880330 | 0.82 | HTT (0.41) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL17333853 | 0.81 | HTT (0.50) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL23525897 | 0.81 | HTT (0.50) | HTTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL1345465 | 0.80 | HTT (0.66) | HTTCYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL2899680 | 0.80 | PTGS2 (0.46) | CYP2C9CYP2C19CYP1A2MEN1KMT2A | |
| SCHEMBL23525873 | 0.78 | SOS1 (0.43) | MEN1KMT2ALMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230137886-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. | 2023-05-04 | — | — | US | disclosed |
| US-20210188857-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137886-A1 | SOS1 INHIBITORS | SOS1, SOS2, SAV1 | HTT 4369/4885CYP2C9 4835/4885CYP2C19 4880/4885 |
| US-20210188857-A1 | SOS1 INHIBITORS | SOS1, SOS2, SOST | HTT 4370/4885CYP2C9 4799/4885CYP2C19 4871/4885 |
| US-11702418-B2 | SOS1 inhibitors | SOS1, SOS2, SOST | HTT 4370/4885CYP2C9 4799/4885CYP2C19 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.