Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | VEGFA | P15692 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862442 | 0.81 | ALDH1A1 (0.60) | VEGFAEGLN1TP53THRBMAPT | |
| SCHEMBL28105762 | 0.77 | VEGFA (0.60) | OPRD1OPRK1VEGFAEGLN1TP53 | |
| SCHEMBL8210703 | 0.77 | KMT2A (0.55) | TP53THRBMAPTALDH1A1CHRM2 | |
| SCHEMBL23529288 | 0.76 | TP53 (0.54) | OPRD1OPRK1VEGFAEGLN1TP53 | |
| SCHEMBL892981 | 0.76 | ALDH1A1 (0.54) | OPRD1OPRK1VEGFAEGLN1TP53 | |
| SCHEMBL23529285 | 0.76 | HTR1A (0.39) | ACHEBRD4KDM4ECHRM4 | |
| SCHEMBL2137893 | 0.76 | ALDH1A1 (0.68) | MAPTMAPK1KDM4EALDH1A1CHRM2 | |
| SCHEMBL23551991 | 0.75 | P2RX3 (0.54) | OPRD1OPRK1VEGFAEGLN1TP53 | |
| SCHEMBL5569584 | 0.74 | GPR119 (0.58) | TP53THRBMAPTALDH1A1CHRM4 | |
| SCHEMBL29132142 | 0.74 | FNTA (0.49) | OPRD1OPRK1KDM4EALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127273-A1 | 1 -((6-OXO-1,6-DIHYDROPYRIDAZIN-4-YL)METHYL)PIPERAZINE AND 1 -((6-OXO-1,6-DIHYDROPYRIMIDIN-4-YL)METHYL)PIPERAZINE DERIVATIVES AS PROLYL HYDROXYLASE, HIF-1 ALPHA AND PGK MODULATORS FOR USE IN TREATING INFLAMMATORY DISEASES, CANCER OR INFECTIONS | GB004, INC. (US) | 2021-06-24 | — | — | WO | disclosed |