SCHEMBL23535535

SCHEMBL23535535

COCCNC(=O)c1ccc(-c2ncc3cnc(-c4cccc(F)c4)cn23)cc1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.47
FYN P06241 9/20 0.45
MAPT P10636 2/20 0.43
LOXL2 Q9Y4K0 1/20 0.43
LMNA P02545 1/20 0.43
TP53 P04637 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
POLB P06746 1/20 0.43
BRAF P15056 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23535507 0.90 FYN (0.48) FYNMAPT
SCHEMBL23535596 0.88 RAB9A (0.53) HPGDFYNLOXL2NPC1RAB9A
SCHEMBL23535518 0.88 FYN (0.45) FYNMAPT
SCHEMBL23535523 0.88 FYN (0.49) FYN
SCHEMBL23547226 0.85 FYN (0.43) FYNMAPT
SCHEMBL23535541 0.83 NAMPT (0.50) FYN
SCHEMBL30014583 0.83 NAMPT (0.50) FYN
SCHEMBL23535526 0.81 POLB (0.55) MAPTNPC1SMN1; SMN2POLB
SCHEMBL30014341 0.81 POLB (0.55) MAPTNPC1SMN1; SMN2POLB
SCHEMBL23535536 0.81 HPGDS (0.49) FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768757-A CD206 modulators and uses and methods of making thereof 美利坚合众国,由健康及人类服务部部长代表 2023-03-07 CN disclosed
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation US HEALTH (US) 2023-02-23 US disclosed
EP-4077297-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) 2022-10-26 EP disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation CD209, MSR1, ARG1 HPGD 1072/4885FYN 1874/4885MAPT 4745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.