SCHEMBL23535596

SCHEMBL23535596

COCCNC(=O)c1ccc(-c2ncc3cnc(-c4ccccc4)cn23)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.53
HPGD P15428 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
NPC1 O15118 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
FYN P06241 10/20 0.49
RAD52 P43351 1/20 0.49
BRAF P15056 1/20 0.48
LOXL2 Q9Y4K0 1/20 0.47
ATM Q13315 1/20 0.47
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 2/20 0.46
TGFBR1 P36897 1/20 0.46
GABRA5 P31644 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23535577 0.88 FYN (0.48) RAB9AFYNRAD52ATMGABRA5
SCHEMBL23535535 0.88 HPGD (0.47) RAB9AHPGDNPC1SMN1; SMN2FYN
SCHEMBL23535524 0.87 FYN (0.61) FYNRAD52
SCHEMBL23535503 0.86 FYN (0.53) FYNRAD52ATM
SCHEMBL28963626 0.85 FYN (0.48) FYNRAD52ATM
SCHEMBL28963628 0.84 ATM (0.48) FYNRAD52ATM
SCHEMBL23535509 0.83 ALDH1A1 (0.51) RAB9AHPGDNPC1SMN1; SMN2ATM
SCHEMBL23535506 0.81 CYP3A4 (0.59) FYN
SCHEMBL23535532 0.81 CD274 (0.66) HPGD
SCHEMBL23535588 0.79 LDHA (0.53) RAB9ANPC1SMN1; SMN2ATMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768757-A CD206 modulators and uses and methods of making thereof 美利坚合众国,由健康及人类服务部部长代表 2023-03-07 CN disclosed
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation US HEALTH (US) 2023-02-23 US disclosed
EP-4077297-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) 2022-10-26 EP disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation CD209, MSR1, ARG1 RAB9A 1254/4885HPGD 1072/4885CYP1A2 1591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.