Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536133 | 0.86 | ICMT (0.31) | ICMTGPR119 | |
| SCHEMBL23536144 | 0.83 | GPR119 (0.31) | GPR119 | |
| SCHEMBL23536597 | 0.82 | GPR119 (0.35) | GPR119 | |
| SCHEMBL23555192 | 0.81 | MC4R (0.32) | GPR119 | |
| SCHEMBL29931913 | 0.80 | MAPK8 (0.34) | GPR119 | |
| SCHEMBL23536408 | 0.80 | MAPK8 (0.34) | GPR119 | |
| SCHEMBL23536277 | 0.78 | GPR119 (0.36) | ICMTGPR119 | |
| SCHEMBL23536132 | 0.78 | — | — | |
| SCHEMBL23536171 | 0.78 | MAOB (0.37) | — | |
| SCHEMBL23536595 | 0.75 | GPR119 (0.38) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |