Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932127 | 1.00 | GRM2 (0.43) | GRM2OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL23536030 | 0.89 | GRM2 (0.43) | GRM2OPRL1KMT2A | |
| SCHEMBL23536137 | 0.81 | GRM2 (0.42) | GRM2OPRL1 | |
| SCHEMBL23536100 | 0.81 | MEN1 (0.49) | GRM2OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL23536068 | 0.80 | OPRL1 (0.41) | GRM2OPRL1C5AR1DRD2KMT2A | |
| SCHEMBL29932148 | 0.80 | OPRL1 (0.38) | GRM2OPRL1DRD4KMT2A | |
| SCHEMBL23536392 | 0.80 | OPRL1 (0.38) | GRM2OPRL1DRD4KMT2A | |
| SCHEMBL23536325 | 0.79 | GRM2 (0.44) | GRM2 | |
| SCHEMBL29931899 | 0.79 | GRM2 (0.44) | GRM2 | |
| SCHEMBL23536314 | 0.79 | GRM2 (0.43) | GRM2OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |