Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536100 | 0.84 | MEN1 (0.49) | GRM2OPRL1 | |
| SCHEMBL23536030 | 0.82 | GRM2 (0.43) | GRM2OPRL1 | |
| SCHEMBL23536314 | 0.82 | GRM2 (0.43) | GRM2OPRL1 | |
| SCHEMBL28867411 | 0.82 | OPRL1 (0.42) | GRM2OPRL1 | |
| SCHEMBL29932127 | 0.81 | GRM2 (0.43) | GRM2OPRL1 | |
| SCHEMBL23536378 | 0.81 | GRM2 (0.43) | GRM2OPRL1 | |
| SCHEMBL29931877 | 0.79 | CA2 (0.43) | GRM2OPRL1 | |
| SCHEMBL29931835 | 0.79 | PGR (0.36) | OPRL1 | |
| SCHEMBL23536154 | 0.77 | OPRL1 (0.42) | GRM2OPRL1 | |
| SCHEMBL23536205 | 0.76 | HTR1A (0.51) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |