Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 10/20 | 0.38 |
| ▸ | SCD | O00767 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536252 | 0.81 | KDM4E (0.51) | THRBALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL21080211 | 0.75 | SMYD3 (0.40) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL21080214 | 0.75 | SMYD3 (0.40) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL29072056 | 0.73 | SCD5 (0.35) | SCD5SCDNPC1RAB9AKDM4E | |
| SCHEMBL2212073 | 0.71 | RAB9A (0.59) | SCD5SCDNPC1RAB9AALDH1A1 | |
| SCHEMBL21162012 | 0.67 | KDM1A (0.42) | NFKB1NFKB2RELA | |
| SCHEMBL3989997 | 0.67 | SCD (0.48) | SCD5SCDNPC1RAB9A | |
| SCHEMBL10323271 | 0.67 | KMO (0.45) | SCD5ALDH1A1HPGD | |
| SCHEMBL5634920 | 0.67 | EPHX2 (0.57) | SMN1; SMN2LMNATSHR | |
| SCHEMBL4706092 | 0.67 | SCD5 (0.34) | SCD5SCDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |