Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26128075 | 0.87 | USP30 (0.43) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL21245644 | 0.85 | KDM4E (0.54) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL30182200 | 0.83 | MAPT (0.49) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL25057572 | 0.82 | THRB (0.48) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL23536110 | 0.81 | SCD5 (0.38) | KDM4ETHRBHTTALDH1A1HPGD | |
| SCHEMBL30182216 | 0.80 | KDM4E (0.46) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL24461435 | 0.79 | KDM4E (0.46) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL31704973 | 0.79 | ALDH1A1 (0.49) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL26683483 | 0.79 | HTT (0.47) | KDM4ETHRBMAPTHTTGPR119 | |
| SCHEMBL7503348 | 0.78 | SMN1; SMN2 (0.53) | KDM4ETHRBGPR119GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127328-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |