Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28867516 | 0.81 | MEN1 (0.47) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL23536096 | 0.80 | MEN1 (0.56) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL17630602 | 0.79 | ADRA2C (0.50) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL30443433 | 0.79 | KEAP1 (0.64) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL127620 | 0.79 | KEAP1 (0.64) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL4937811 | 0.79 | HRH3 (0.47) | MEN1KMT2ACYP2C9 | |
| Hydrochloric Acid SCHEMBL23536416 | 0.78 | KEAP1 (0.62) | MEN1KMT2AUSP2GAAKEAP1 | |
| Hydrochloric Acid SCHEMBL9424019 | 0.78 | KEAP1 (0.62) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL3435080 | 0.78 | MEN1 (0.57) | MEN1KMT2AUSP2GAAKEAP1 | |
| SCHEMBL29367 | 0.78 | MAPT (0.46) | MEN1KMT2AUSP2GAAADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |