Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932103 | 1.00 | TSHR (0.38) | TSHRNPSR1LMNASMN1; SMN2GAA | |
| SCHEMBL24628363 | 0.87 | LMNA (0.44) | TSHRNPSR1LMNASMN1; SMN2GAA | |
| SCHEMBL29772850 | 0.87 | LMNA (0.44) | TSHRNPSR1LMNASMN1; SMN2GAA | |
| SCHEMBL29932107 | 0.87 | ALDH1A1 (0.37) | TSHRNPSR1SMN1; SMN2GAATP53 | |
| SCHEMBL29931867 | 0.87 | TSHR (0.39) | TSHRNPSR1LMNASMN1; SMN2GAA | |
| SCHEMBL23536124 | 0.87 | TSHR (0.39) | TSHRNPSR1LMNASMN1; SMN2GAA | |
| SCHEMBL23536392 | 0.85 | OPRL1 (0.38) | TSHRNPSR1GAATP53GRM2 | |
| SCHEMBL29932148 | 0.85 | OPRL1 (0.38) | TSHRNPSR1GAATP53GRM2 | |
| SCHEMBL23535984 | 0.85 | HTR1A (0.42) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL29932077 | 0.85 | HTR1A (0.42) | LMNASMN1; SMN2GAAHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |