Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536183 | 0.81 | ALDH1A1 (0.39) | MEN1GAAKMT2A | |
| SCHEMBL23535973 | 0.75 | CYP2A13 (0.34) | MEN1USP2GAAKMT2AHRH4 | |
| SCHEMBL23536058 | 0.75 | CYP2A13 (0.34) | MEN1USP2GAAKMT2AHRH4 | |
| SCHEMBL28867487 | 0.74 | MEN1 (0.33) | MEN1USP2GAAKMT2AHRH4 | |
| SCHEMBL23536077 | 0.73 | BPTF (0.35) | USP2GAA | |
| SCHEMBL29932019 | 0.72 | MCOLN2 (0.49) | KMT2A | |
| SCHEMBL14804508 | 0.71 | BPTF (0.38) | MEN1USP2GAAKMT2A | |
| SCHEMBL14804532 | 0.71 | OPRL1 (0.39) | MEN1USP2GAAKMT2AHRH4 | |
| SCHEMBL30667343 | 0.69 | KEAP1 (0.47) | MEN1USP2GAAKMT2A | |
| SCHEMBL12070271 | 0.68 | MAPT (0.46) | MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |