Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931878 | 1.00 | LMNA (0.37) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29931931 | 0.87 | DRD2 (0.36) | PROKR1OPRL1 | |
| SCHEMBL29932243 | 0.74 | LMNA (0.38) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536043 | 0.74 | LMNA (0.38) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29932092 | 0.73 | LMNA (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536355 | 0.73 | LMNA (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536117 | 0.72 | POLB (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29931921 | 0.72 | POLB (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536124 | 0.72 | TSHR (0.39) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29931867 | 0.72 | TSHR (0.39) | LMNATP53GAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |